With the Hillsborough River flowing through downtown and bays that provide a direct path to the Gulf of Mexico, Tampa is perfectly situated for cruise ships to set sail year-round from its port. Located in West Central Florida near Wesley Chapel FL. Wesley Chapel is an unincorporated census-designated place in Pasco County, Florida, United States. It is part of the Tampa Bay Area metro. proximity to Interstate 75 and Interstate 275, 25 miles north of Downtown Tampa, and other major locales. Adjacent to its south is the region of New Tampa, part of incorporated Tampa.